实验动物科学 ›› 2016, Vol. 33 ›› Issue (05): 57-60.

• 研究 论著 • 上一篇    下一篇

氯胺酮和速眠新Ⅱ复合麻药剂量对巴马小型猪的麻醉效果及影响

  

  1. ( 首都医科大学实验动物部,北京100069)
  • 出版日期:2016-10-31 发布日期:2017-06-07
  • 基金资助:

    <p>基金项目: 本研究得到首都医科大学校长基金的资助( No. 1140170256)</p>

The Anesthesia Effects of Ketamine and Sumianxin Ⅱ on Bama MiniPig

  • Online:2016-10-31 Published:2017-06-07

摘要: 摘要: 目的研究氯胺酮和速眠新Ⅱ复合麻醉方法用于巴马小型猪实验的麻醉效果,初步观察复合麻药对动物机能指标的影响。方法使用氯胺酮和速眠新Ⅱ按2∶ 1. 5( mL) 的体积制成混合麻醉剂,在0. 3—0. 5 mL/kg 的剂量范围内,给予动物一定剂量的麻药进行麻醉,记录麻药剂量、麻醉效果和生理指标。结果随着麻醉剂量的增加,麻药起效时间、肌松时间和眼睑反射消失时间均降低; 动物心率和呼吸频率增加,对血压影响不大。结论0. 3—0. 4 mL/kg 可以作为安全剂量用于小型猪的麻醉,不但起到良好的麻醉效果,对生理指标影响也不大。

关键词: <, p>, 巴马小型猪, 氯胺酮, 速眠新Ⅱ, 麻醉<, /p>

Abstract: Abstract: Objective To study the anesthesia effect of Ketamine and Sumianxin Ⅱ on minipigs,to investigate the effects of two kinds of anesthetic on physiology of animal. Method Ketamine and Sumianxin Ⅱ were mixed together,the volume ( between 0. 3 to 0. 5 mL /kg) of the mixture was used for anesthesia,then the anesthetic effect and physiology index were recorded. Result With the increasing of anesthesia dose,the length of anesthesia effect - act,muscle relaxant and eyelid reflex disappearing were decreasing. The heart rate and respiratory rate of animals in high dose ( 0. 4—0. 5 mL /kg) group higher than low dose ( 0. 3—0. 4 mL /kg) group. The mean arterial pressure and the oxygen saturation were similar between two groups. Conclusion 0. 3—0. 4 mL /kg could be used safely for anesthesia on minipig ,this dose could offered not only good anesthesia effect but also little impact on physiology indexes.

Key words: <p>Bama minipig, Ketamine, Sumianxin Ⅱ, anesthesia</p>

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