实验动物科学 ›› 2014, Vol. 31 ›› Issue (06): 43-46.

• 研究 论著 • 上一篇    下一篇

手术建立 Beagle 犬遥测动物模型的经验体会

  

  1. ( 中国食品药品检定研究院国家药物安全评价监测中心,药物非临床安全评价研究北京市重点实验室,北京 100176)
  • 出版日期:2014-12-29 发布日期:2016-12-07
  • 基金资助:

    “十二五”国家科技重大专项“药物安全评价技术平台”课题资助项目( No. 2012ZX09302001)

Experience for the Establishment of the Beagle Dog Telemetry Model with Surgery

  • Online:2014-12-29 Published:2016-12-07

摘要: 摘要: 目的 探讨 Beagle 犬遥测动物模型建立及应用过程中遇到的问题,并提出相应的预防处理措施。方法 回顾了我单位 32 例 Beagle 犬遥测动物模型在建立及应用中出现的问题,分析了常见的切口感染、动物自主拆线、毛 囊炎等临床异常的产生原因,介绍了解决上述临床异常情况的预防和处理方法。结果 分析并解决了 Beagle 犬遥 测动物模型建立过程中出现的临床异常情况。结论 成功建立 Beagle 犬遥测动物模型,对国内遥测模型在安全药 理学评价方面的使用和维护起到一定的借鉴作用。

关键词: 遥测模型, 手术, Beagle 犬

Abstract: Abstract: Objective The some problems during the establishment and application of the Beagle dog telemetry model were investigated,and introduce the measures to prevent such problems. Method The problems during establishment and application of the Beagle dog telemetry model have been investigated using 32 Beagle dogs. The reasons of such clinical abnormalities as wound infection,suture removal by the animal and folliculitis have been analyzed. Correspondingly,certain advices on how to prevent and treat these clinical abnormalities have been proposed. Result The clinical abnormalities during the establishment and application of the Beagle dog telemetry model have been analyzed and solved. Conclusion The Beagle dog telemetry model was successfully established and valuable information was provided for the application and maintenance of the telemetry model in the safety pharmacology evaluation in our country.

Key words: telemetry model, surgery, Beagle dog

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