实验动物科学 ›› 2010, Vol. 27 ›› Issue (06): 16-19.

• 研究 论著 • 上一篇    下一篇

大鼠腹部异位心脏移植模型的建立及改进

  

  1. (北京大学第三医院普通外科,北京100191)
  • 出版日期:2010-12-31 发布日期:2013-06-06
  • 基金资助:

    国家自然科学基金资助项目(编号:30872556)

Improvement of Model Establishment of Abdominal Heterotopic Heart Transplantation in Rats

  • Online:2010-12-31 Published:2013-06-06

摘要: 目的建立大鼠腹部异位心脏移植模型。方法选用近交系DART-La大鼠和LEWRT-L11大鼠分别作为供体 和受体,在经典的Ono术式的基础上加以改进,使改进后的移植模型更加稳定,移植物存活率高、可操作性更强。 结果共进行了32对心脏移植,28对成功,手术成功率87.5%。供心缺血时间(30±5)min,整个手术过程用时 (60 4-10)min。结论在经典的Ono心脏移植模型基础上改进后,手术操作更简易,时间缩短,供体心脏保护好,血 管缝合难度降低。手术成功率高。整个手术过程单人操作,不需要手术显微镜。

关键词: 心脏移植, 大鼠, 模型

Abstract: Objective To establish the model of abdominal heterotopic heart transplantation.Methods DA‘¨1‘’ and LEW(盯‘1¨rats were adopted in the study as the donor and recipient.and Ono’s transplant model was improved to make the transplant model more steady and more operational.Results 32 heterotopie heart transplantations were performed,28 succeed,and the successful rate was 87.5%.Conclusion After the improvement,the operation became easier and the operation time was shorten with lower difficulty in stitch and higher successful rate.

Key words: Cardiac transplantation, Rat, Model

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