关键词: 肿瘤移植, 免疫缺陷小鼠, 肝转移

Abstract: Trying to elucidate the mechamism and biological charateristics of metastatic formation of tumor cell in liver, human nasopharygeal carcinoma (CNE-2Z) and mice uterine cervical carcinoma (U14) were intrasplenicly innoculeted into nude mice and inbred 615 mice respectively. Forty three to fifty days after implantation tumor nodules in spleen and hepatic metastasis were detected in 8/10 cases of CNE-2Z group, of them four cases concurred with pulmonary metastasis. For the U14 group, the mice were sacrificed on the 13rd or 14th day, hepatic metastasis occurred in 73% cases with various degree of pulmonary or/and lymphatic metastasis, of those with primary nodule resection one day or three days after implantation, 11% and 63% demostrated hepatic metastasis respectively. It is suggested that once there is enough tumor cells innoculated into the spleen, a primary tumor would occur in it, and then spreading via blood circulation, secodary metastatic tumor would formed in liver.

Key words: Implantation tumor, Immunodeficient, Liver metastasis