关键词: 小型猪, 冠状动脉造影, 冠状动脉支架

Abstract: Objective The aim of this study is to summarize the characters，limitation and technical main point of Bama and Guizhou mini—swines’coronary artery and evaluate the application of the two strains of swine in coronary stent model．Methods Nine Bama and 12 Guizhou mini—pigs were used，male and female．After general anesthesia，the animals were weighed and the right femoral artery was exposed．Then coronary angiography was performed and recorded．Coronary stent was chosen according to the diameter of left anterior descending and right coronary artery by visual observation and implanted by overexpansion(artery diameter：stent diameter=1：1．2)． Coronary angiography was repeated to investigate the adherence of stent．The pigs were fed a standard laboratory chow after stinting until they were anesthetized again 26 weeks later．The style，curvature and diameter of coronary artery were detected by catheter doctor depending on the coronary angiography．Results All animals survived 26 weeks and had right—side dominance type coronary artery with curvature<30o．There was no statistic difference in the diameter of LAD between Bama and Guizhou mini·swine(P>0．05)．The diameter of RCA in Bama was smaller than that in Guizhou(P<0．05)．The diameter of stent was no statistic different either in LAD or RCA between Bama and Guizhou(P>0．05)．The weight changing of Bama was bigger than that of Guizhou(P< 0．001)．Conclusions In our study。the adult animM of both Bama and Guizhou was found with right—side dominance type just like human．The curvature of LAD or RCA is suitable to intervention．The diameter of stent is 2．75 mm or 3．0 mm can be implanted easily．Both Bama and Guizhou are fit for coronary stent model through a live and dynamic coronary angiography analysis。

Key words: mini-swine, coronary angiography, coronary stent