关键词: 酒精性肝损伤, 氧化应激, 能量代谢

Abstract: To observe the different effects of wine spirit and red wine on liver;to interpret the relationship between alcoholic liver disease and hepatoma in terms of oxidative stress and energy metabolism then to explore pharmacology mechanism of Hu Qi San(HQS) intervening the malignant transformation of alcoholic liver disease.KM strain male mice were randomly divided into normal group,white spirit group,red wine group and HQS group.After 14 days,the MDA,SOD and CAT in serum were detected by colorimetry.HE staining,PAS staining,G-6-P staining,SDH staining and ATPase staining were on the liver tissue.In white spirit group,the contents of MDA,the index reflected lipid peroxidation,were significantly increased,the activities of SOD,CAT and the key enzymes about energy metabolism such as G-6-P,SDH and ATPase were restrained.The red wine had no damage on liver.HQS decreased the level of MDA,improved the activities of antioxidant enzymes and the energy metabolism key enzymes;PAS staining revealed an increase of glycogen granules.These experimental results indicated that long-term intake of ethanol causes some damage to liver,but red wine causes no.HQS has intervention effect on alcoholic liver disease.

Key words: Alcoholic liver disease, Oxidative stress, Energy metabolism, Hu Qi San