关键词: 胰腺炎, 胰腺处方粮, 白藜芦醇, 血浆代谢组学, 代谢稳态

Abstract: Objective This study aimed to prepare a self-developed canine pancreatic prescription diet supplemented with blueberry extract rich in resveratrol and systematically evaluate the regulation and improvement effects on healthy pastoral canine physical status and metabolic homeostasis. Method Healthy dogs fed with self-developed prescription diet or control diet for 8 weeks, respectively. Physical examination, whole blood cell count and serum biochemistry test were carried out in dogs at 0 and 8 weeks of the experiment, and plasma was collected for untargeted metabolomics analysis. Result Compared with the control group, other physiological and biochemical indicators showed no abnormalities in addition to the reduction of total cholesterol in dogs fed with self-developed prescription diet for 8 weeks. Plasma metabolomics showed that self-developed prescription diet feeding promoted glutathione and arginine metabolism in healthy dogs. Conclusion The above metabolic process has been reported to be clearly related to the occurrence of pancreatitis, suggesting the self-developed prescription diet has the potential function of protecting pancreas and regulating metabolic balance.

Key words: pancreatitis, pancreatic prescription diet, resveratrol, plasma metabolomics; metabolic homeostasis