关键词: 小鼠, 基础群, 生物学特性, 血液生理生化, 脏器系数

Abstract: Objective　To promote the open sharing and standardized application of C57BL/6JNifdc, C57BL/6N,DBA/1J,DBA/2Nifdc,FVB/NJNjuNifdc,A/J,129S1/SvlmJ and C3H/HeJNifdc-eight inbred strains of mice preserved in the National Rodent Laboratory Animal Resources Center, this study was conducted.Methods　For each strain, 20 male and 20 female mice were selected. Venous blood was collected, and major organs (heart, liver, spleen, lungs, kidneys, thymus) were harvested at 4 and 8 weeks of age. A systematic analysis of 23 hematological parameters, 9 biochemical parameters, and 7 organ coefficients was performed using automated blood cell analyzers, biochemical analyzers, and electronic balances. Data are presented as mean±standard deviation, and statistical analysis was conducted using the t test.Results　The blood physiological, biochemical and major organ coefficient indicators varied across strains with different genetic backgrounds, as well as across different ages and sexes. The organ coefficients of DBA/1J and DBA/2Nifdc were affected by age or gender in a similar way. Compared with other strains, C57BL/6JNifdc and C57BL/6N were more similar in biological characteristics, especially in blood biochemical aspects. Compared with previous studies, the mean PLT related values determined in this study for C57BL/6JNifdc, FVB/NJNjuNifdc and C3H/HeJNifdc were higher, and the CRE were relatively lower.Conclusion　This study systematically updated and expanded the background biological database for 8 inbred mouse strains, clarifying the distinctive characteristics of each strain in terms of hematological, biochemical, and organ coefficient profiles. It provides essential data support for the standardization of laboratory animal strains, model construction, and experimental design. 

Key words: mouse, foundational colony, biological characteristics, blood physiology and biochemistry, organ coefficients