关键词: 乳腺生物反应器, 转基因动物, 生物制药, 改善乳成分

Abstract: Animal mammary gland bioreactors use transgenic technology to introduce exogenous genes into animal genomes and locate and express them in animal mammary glands, and then utilize the ability of animal mammary glands to synthesize and secrete proteins naturally and efficiently to produce some valuable products in animal milk. This technology has the advantages of low cost, high quality, high biological activity, no pollution, and high yield. It has created a new way of biopharmaceuticals and has broad development prospects. In this paper, a brief review and prospect of the application research, technical method, future application prospects and challenges of animal milk “ humanization” in the field of biopharmaceuticals and improving milk composition are made.

Key words: mammary gland bioreactor, transgenic animals, biopharmaceuticals, improving milk composition