关键词: 2 型糖尿病, 男性不育, 炎性反应, 内质网应激, 糖脂代谢

Abstract: In recent years, male reproductive disorders caused by diabetes have become the focus of human attention as the global infertilities of young people is increasing in reproductive age. Diabetes is a chronic metabolic syndrome caused by a relatively low insulin secretion that leads to elevated blood glucose. The major vascular complications caused by diabetes include diabetic cardiomyopathy, diabetic nephropathy and retinopathy, among which reproductive function injury is also one of them. The mechanism of diabetic testicular tissue damage involves many aspects, including glucose and lipid metabolism, oxidative stress, inflammatory response, endoplasmic reticulum stress, autophagy and so on. In this review, the pathogenesis of male reproductive disorders induced by diabetes was briefly introduced, which provided a new research idea for further exploring the damage of high glucose on testicular spermatogenic cells, and a new drug target for clinical treatment.

Key words: type 2 diabetes, male infertility, inflammatory response, endoplasmic reticulum stress, glucose and lipid metabolism