关键词: 无菌鼠, 剖腹取胎无菌饲养法, 抗生素鸡尾酒法, 伪无菌鼠, 动物模型

Abstract: The successful breeding technology of germ-free animals, especially germ-free rats and mice, has become the key technology to study the relationship between microorganisms and human life phenomena. Strict germ-free animal means that no living body can be detected in any part of the host and living environment. In a broad sense, germ-free animals also include animals that clear most of the intestinal flora, also known as pseudo germ-free animals. At present, the method of making germ-free rat or mice mainly include the method of caesarean section and aseptic feeding, and the method of antibiotic cocktail. In this paper, the method of making germ-free rats and
mice model were summarized and evaluated.

Key words: germ-free rats and mice, the method of caesarean section and aseptic feeding, the method of antibiotic cocktail, pseudo germ-free rats and mice, animal model