关键词: 11β-羟基类固醇脱氢酶 1, 大黄素, 非酒精性脂肪肝, 大鼠

Abstract: Objective To observe the effect of emodin on nonalcoholic fatty liver disease ( NAFLD ) and the expression of 11β-HSD1 in liver. To investigate the expression changes of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the liver of rats with nonalcoholic fatty liver ( NAFLD) and the intervention effect of emodin. Method 40 male Wistar rats were randomly divided into four groups: control, model, low-dosage emodin treatment ( E1) and high-dosage emodin treatment ( E2) groups. The control group was feed with normal diet, the model and treatment group were feed with high-fat diet. The treatment group was given emodin from the 9th week, and the experiment was completed at the end of the 14th week. Result Compared with the control group, rats in the model group had significant NAFLD, and the expression of 11β-HSD1 in liver was increased. Compared with the model group, emodin treatment could reduce liver index, blood lipid and liver lipid deposition, improve liver function and pathological changes, and significantly inhibit the expression of 11β-HSD1 gene and protein in liver tissue. All emodin treatment effects were dose-dependent. Conclusion Emodin has a significant protective effect on NAFLD, which maybe related to the inhibition of the 11β-HSD1 activity.

Key words: 11β-hydroxysteroid dehydrogenase type 1, emodin, nonalcoholic fatty liver disease, rat