关键词: 急性心力衰竭, 动物模型, 造模方法

Abstract: Acute heart failure (AHF) is a clinical syndrome that rapidly develops or worsens due to abnormal cardiac function. The pathogenesis of AHF is complex, and it occurs suddenly, posing a serious threat to human life and health and bringing a heavy economic burden to society. Therefore, it is of great significance to study and prevent AHF. AHF animal models can simulate the pathogenesis of heart failure by simulating the pathogenesis of AHF. They can be used to simulate and study the pathogenesis of AHF, diagnostic method, and the effectiveness of new treatment strategies. The commonly used modeling method can be divided into surgical and non-surgical method based on whether surgery is required. Surgical method include coronary artery ligation, ex vivo AHF modeling, and pulmonary artery thrombosis models. Non-surgical method include chemical agent induction, rapid ventricular pacing, and pulmonary artery thrombosis models. By comprehensively discussing the  mechanisms,advantagesanddisadvantages,and applicable scenarios of variousmodelingmethod, this paper aims toprovide reference for animal experiment design.

Key words: acuteheart failure, animalmodels, modelingmethods