关键词: 动物实验, 福利伦理审查, 伤害—利益分析

Abstract: Conducting “Harm-Benefit Analysis” before animal experiments has become an internationally recognized prerequisite for the use of animals in research and testing. The use of animals for research should be ethically evaluated based on the understanding that the use will provide significant new knowledge facilitating relevant benefits and no unnecessary harm imposed on the animals. In China, the “ Laboratory animal—Guideline for ethical review of animal welfare ” ( GB / T 35892—2018 ) also presents corresponding requirements in the section on the “ principle of balance of interests” . It explicitly mandates filling out the “Experimental Animal Welfare Ethical Review Form” appendix with a “ summary of potential harms and benefits ” . However, both local and international institutions may face the challenge in implementing the harm and benefit analysis. This paper is based on the report from the American Association of Laboratory Animal Science-Federation of European Laboratory Animal Science Association ( AALAS-FELASA ) expert working group on Harm-benefit analysis. It introduces the framework and approach for HBA, and its concepts, two models ( discourse model and metric model) of harm-benefit analysis, how to utilize the harm / benefit assessment framework system for analysis, and current focal points for discussions. The aim of this paper is to provide guidance for local institutions or organizations on evaluating the ethical use of animals in research and testing by the use of harm-benefit analyses. 

Key words: experimental animal, welfare and ethical review, Harm-benefit analysis