实验动物科学

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犬细小病毒免疫球蛋白的有效性评价

  

  1. 长春西诺生物科技有限公司
  • 出版日期:2020-10-28 发布日期:2021-02-25

Evaluation of the Effectiveness of Canine Parvovirus Immunoglobulin #br#

  • Online:2020-10-28 Published:2021-02-25

摘要:

摘要:目的 探究犬细小病毒免疫球蛋白注射液的有效性。 方法 将实验犬分为模型对照组、对症治疗组与球蛋白治疗组,所有犬同时进行人工感染犬细小病毒,在实验犬发病后根据每日的状态,对症治疗组与球蛋白治疗组进行相应的治疗,球蛋白治疗组除进行与对症治疗组相同的治疗外,加入犬细小病毒免疫球蛋白的注射治疗。每日观察临床症状并进行评分,采集肛拭子用胶体金抗原检测试纸判断粪便排毒情况;每日采血,进行血常规及血液生化检测,对检测结果及实验犬死亡后解剖结果进行分析,根据模型对照组对另外 2 个治疗组的治疗效果进行对比。结果 所有实验犬发病率 100% ,模型对照组的好转率为 20% ,对症治疗组的好转率为 40% ,球蛋白治疗组的好转率为 80% 。 结论 通过人工感染模型与治疗组间的治疗效果对比,证实了犬细小免疫球蛋白注射液具有治疗犬细小病毒病的效果。

Abstract:

Abstract: Objective To explore the effectiveness of canine parvovirus immunoglobulin injection. Method In this experiment, the canines were divided into model control group, symptomatic treatment group and globulin treatment group, and artificial infection of canine parvovirus was carried out. After the onset of the canines, the symptomatic treatment group and the globulin treatment group were treated according to the daily state. The experimental group was injected with canine fine immunoglobulin in addition to the same adjuvant therapy as the symptomatic treatment group. To observe clinical symptoms and score daily, collect anal swabs to detect fecal detoxification with colloidal gold antigen test strips; daily blood collection, perform blood routine and blood biochemical tests, analyze the test result and anatomical result . For analysis, the treatment effects of the other two treatment groups were compared according to the model establishment group. Result The result showed that the incidence rate of all dogs was 100%, the improvement rate of the model control group was 20%, the improvement rate of the symptomatic treatment group was 40%, and the improvement rate of the test treatment group was 80%. Conclusion The result show that the comparison of the treatment effect between the artificial infection model and the treatment group confirms that the canine parvovirus injection has the effect of treating canine parvovirus disease.