关键词: 高盐, 高蛋白, 肾脏, 消化道

Abstract: Abstract: Objective To explore the effect of high salt and high protein diet on blood pressure and the pathology changes of kidney and gastrointestinal in Dah1 / SS rats． Method SPF female Dah1 / SS rats were respectively randomly divided into three groups: control，high-salt and high-protein group，and were respectively fed to common low-salt diet，high-salt diet witch contain 8% sodium chloride and high-protein diet with 2. 4% methionine in the individual ventilated cages ( IVC) ． Systolic blood pressure ( SBP) and body weight of rats was measured every week． At 8 weeks，the kidney，esophagus，stomach ，small intestine ，rectum，and pancreas tissues were stained with HE to observe the pathological changes． Result The rat body weight of high-salt and high-protein group were significantly lower than the control group，but the SBP of high-salt group was significantly higher than control and high-protein group． Renal impairment was observed in high-salt and high-protein group． Besides，the pathological changes of kidney were observe only in high-salt group． Also，the pathological changes of esophagus，stomach， small intestine，rectum，and pancreas tissues were not found． Conclusion The salt-sensitive hypertension model was successfully made by Dah1 / SS rats fed with high salt diet，and the varying degrees of damage of kidney with high salt and high protein diet，but no damage to gastrointestinal and pancreas．

Key words: high salt diet, high protein diet, kidney, gastrointestinal