关键词: 桥本甲状腺炎, 动物模型, 优缺点, 评估

Abstract: Hashimoto’s thyroiditis is a common endocrine disease in clinical practice. In recent years, the incidence of Hashimoto’s thyroiditis has increased year by year, which has attracted widespread attention. The successful establishment of animal model of Hashimoto’s thyroiditis is of great significance for study of pathological mechanism and pharmacodynamic effect of this disease and the improvement of clinical efficacy. However, there are few basic studies on the pathogenesis and efficacy observation of Hashimoto’s thyroiditis based on animal models, which is related to the difficulty of establishing relevant animal models. In this paper, the method of establishing animal models of Hashimoto’s thyroiditis in recent years were summarized, and the advantages and disadvantages of various models were discussed to provide theoretical basis for the development of basic experiments.

Key words: Hashimoto’s thyroiditis, animal model, advantages and disadvantages, evaluate