关键词: 慢性肾病, 动物模型, 研究进展

Abstract: Chronic kidney disease (CKD) is a major global medical problem affecting millions of people, and its incidence has increased rapidly in recent years due to the increased prevalence of hypertension and diabetes, with 30%-40% of patients progressing to end-stage renal disease within 20 years of diagnosis. Many rodent models of chronic kidney disease (CKD) have been developed to elucidate the pathogenesis of CKD and to investigate new therapeutic approaches for CKD. These models have been developed by surgical, drug-induced, and genetic engineering approaches, or a combination of two or more approaches. The characteristic structures of CKD, including tubular atrophy, tubulointerstitial fibrosis, glomerulosclerosis, and focal hypertrophy, should be manifested in animal models of CKD. However, rodent models with all of the above features of human CKD have not been established. In addition, sex, genetic background and strain differences also show different levels of susceptibility to CKD with respect to the development of glomerular and tubulointerstitial lesions. In this review, we discussed the advantages and disadvantages of different rodent models used to study CKD to provide ideas and lessons for researchers.

Key words: chronic kidney disease, animal model, research progress