实验动物科学 ›› 2024, Vol. 41 ›› Issue (1): 94-98.DOI: 10. 3969 / j. issn. 1006-6179. 2024. 01. 017

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运动病动物模型研究新进展

  

  1. ( 1. 延安大学医学院病理与病理生理学科组,延安 716000) ( 2. 中国人民解放军空军军医大学航空航天医学系航空航天临床医学
    中心,西安 710032) ( 3. 中国人民解放军空军军医大学第一附属医院空勤科,西安 710032) ( 4. 中国人民解放军联勤保障部队第 908 医院耳鼻咽喉头颈外科,南昌 360104)
  • 收稿日期:2022-06-14 出版日期:2024-02-28 发布日期:2024-03-15
  • 通讯作者: 王小成( 1978—) ,男,博士,副教授,研究方向为耳内科疾病的基础与临床,E-mail:wxcnose@ 126. com。 周小燕( 1967—) ,女,博士,教授,研究方向为疾病预防与控制,E-mail:xyzchc@ 163. com。
  • 作者简介:张卓儒( 1998—) ,女,硕士研究生,研究方向为前庭系统疾病机制与防治,E-mail:wxzhangzr@ 163. com。
  • 基金资助:
    军队保健专项科研课题( 17BJZ24)

Research Advances of Experimental Animal Models of Motion Sickness

  1. ( 1. Department of Pathology and Pathophysiology, Medical College of Yan’ an University, Yan’ an 716000,China) ( 2. Center of Clinical Aerospace Medicine, School of Aerospace Medicine, PLA Air Force Medical University, Xi’ an 710032, China) ( 3. Department of Aviation Medicine, the First Affiliated Hospital, PLA Air Force Medical University, Xi’ an 710032, China) (4. Department of Otolaryngology-Head and Neck Surgery, the 908th Hospital, PLA Joint Logistics Support Force, Nanchang 360104, China)
  • Received:2022-06-14 Online:2024-02-28 Published:2024-03-15

摘要: 随着运动病研究的不断深入,运动病模型的动物种类不断增多,判断标准和指标逐渐采用客观的行为学指标和生理学指标结合的方法。 本文就近年来常用的运动病动物模型,从动物种类、造模方法和模型标准与判断指标,分析总结其方法和特点,整理收集运动病动物模型的评价方法,为运动病发病机制的探索、疾病严重程度客观评价、抗运动病药物研发及前庭稳定性训练方案制定等研究提供可靠的实验动物建模方法和观察指标。

关键词: 运动病, 动物模型, 建模方法, 评价方法

Abstract: With the deepening of the research on motion sickness, the types of animal models of motion sickness are increasing, and the method of combining objective indicator of behavior and physiological indexes are gradually adopted as the criteria and indicators. This paper analyzes and summarizes the method and characteristics of animal models of motion sickness commonly used in recent years from the animal types, modeling method, model standards and indicators, and collects the evaluation method of animal models of motion sickness. To provide a reliable experimental animal modeling method and observation index for the exploration of pathogenesis of motion sickness, the objective evaluation of disease severity, the development of anti-motion sickness drugs and the development of vestibular stability training program.

Key words: motion sickness, animal model, modeling approach, evaluation methods

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