关键词: 抑郁症, 啮齿类动物, 行为学

Abstract: Rodent animal is an important model for the study of mechanism and drug of depression because it can better simulate a series of biochemical changes of human depression. Behavioral experiments are widely used to evaluate animal models and drug efficacy of neuropsychiatric diseases such as depression. However, the animal behavior evaluation method related to depression are complex, each has its own advantages and disadvantages, and there is no unified operation standard or evaluation standard. Therefore, this paper aims to summarize the experimental principles and operational method of depression-related behavioral evaluation in rodents, and review the advantages and disadvantages as well as the improved method, so as to provide a basis for establishing stable and reliable behavioral evaluation standards for depression in animals.

Key words: depression, rodents, behavioral evaluation