关键词: 白化鼠, 非白化鼠, SD 大鼠, BN 大鼠, 模拟失重, 视网膜退行性病变

Abstract: Objective To compare the changes of ocular structure and function in albino rats and nonalbino rats after simulated long-term microgravity exposure, and to improve and supplement the animal model of ocular injury caused by simulated long-term microgravity exposure. Method Male SD and BN rats, each 12, were randomly divided into control group (NS and NB ) and model group ( MS and MB ) . 30 ° headed-down tail suspension for 8 weeks was used to simulate microgravity for model group. At the end of the model, electroretinogram (ERG) and visual evoked potential (VEP) were used to detect the function of retina. The morphology of retina was observed by HE staining, and the changes of blood vessels in fundus were observed by small animal fundus imaging system. Result After 8 weeks of simulated weightless suspension, the structure and function of the retina of Sprague-Dawley rats ( SD, albino rats) changed significantly, and the amplitude of ERG dark adaptation 3. 0 response decreased significantly (P< 0. 01) , the peak time of P1 wave of VEP was significantly prolonged (P<0. 01) , HE staining showed thinning of the outer nuclear layer (P<0. 01) , increased blood flow of choroidal vessels was observed in the fundus, while there were no significant changes in retinal structure and function in Brown-Norway rats (BN, non-albino rats) after suspension. Conclusion Albino rats exhibit heightened vulnerability to ocular damage when exposed to prolonged simulated weightlessness, thus warranting investigation into the role of melanin synthesis-associated proteins within the retinal pigment epithelium as a potential means of mitigating retinal degeneration induced by prolonged simulated weightlessness.

Key words: albino rats, non-albino rats, SD rats, BN rats, simulated weightlessness, degeneration of the retina