关键词: 嗜黏蛋白阿克曼菌;Amuc_1100, 代谢疾病;肠道菌群;炎性肠炎病

Abstract: Gut microbiota plays an important role in the regulation of host metabolism and low-grade inflammation, and the occurrence of many diseases is closely related to gut microbiota dysbiosis. Akkermansia muciniphila ( A. muciniphila ) is the only cultivated intestinal representative of the Verrucomicrobia and was isolated from a human fecal sample. Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. There has also been a growing interest in A. muciniphila, due to its association with health in animals and humans. Notably, reduced levels of A. muciniphila have been observed in patients with inflammatory bowel diseases ( mainly ulcerative colitis ) and metabolic disorders, which suggests it may have potential antiinflammatory properties. The aims of this review are to systemically summarize the existing data on the relationship between the A. muciniphila with intestinal immunity and the metabolic diseases. With a specific focus on the mechanisms of inflammatory bowel diseases and metabolic disorders in both animals and humans, which is expected to provide evidence and routes for effective utilization of this bacterial species.

Key words: Akkermansia muciniphila, Amuc _ 1100, metabolic diseases, intestinal microflora, inflammatory bowel diseases