关键词: 脑爆震伤, 动物模型, 大鼠

Abstract: Objective To establish a stable, simple and safe animal model and evaluation system for blast-related traumatic brain injury ( bTBI) . Method After anesthesia, rats were placed inside a steel pipe with an inner diameter of 6 cm, and explosive devices devices with a TNT content 0. 1 g were placed 7 or 9 cm away from the head of the rats. The physiological characteristics of the rats were observed before and after the explosion. The Garcia scoring method was used to score their neurological function of the rats. 6 hours later, the brain tissues were observed the changes, evaluated the cerebral edema, and observed pathological changes in brain tissues HE staining. Result After the experiment, the nerve function of the rats was damaged and the brain tissue edema appeared. HE staining was used to observe the bleeding of the brain tissue. The explosive device was 9 cm away from the head of the rats, and the brain explosion injury was more serious at 7 cm away. Conclusion It is safe, stable and a reliable method to construct the model of brain blast injury in rats with simple modeling device.

Key words: brain blast injury, animal model, rat