Abstract: Objective　To investigate the effect of age and sex on basal blood indicators of Beagle dogs. Methods　Blood samples were collected from Beagle dogs of both sexes during the juvenile (6-8 months), young adulthood (2-3 years), adulthood (4-5 years), and senior (8-9 years) stages. The blood cell analyzer was used to measure the white blood cell count, red blood cell count, hemoglobin content, hematocrit, mean corpuscular volume, red blood cell distribution width, mean corpuscular hemoglobin, and erythrocyte sedimentation rate in the blood. The result were statistically analyzed. Results　The test result showed that the number of lymphocytes in the blood of female dogs aged 6-8 months was significantly higher than that of male dogs and female dogs aged 8-9 years (P<0.05),and the red blood cell count and hemoglobin content were significantly lower than those of 4-5-year-old male dogs (P<0.05), and the erythrocyte sedimentation rate was significantly higher than that of 4-5-year-old and 8-9-year-old female dogs (P<0.05). The platelet count in the blood of 2-3-year-old young dogs was the lowest, and the erythrocyte sedimentation rate was significantly lower than that of 4-5-year-old and 8 9-year-old female dogs (P<0.05), but slightly higher than 6-8 months old younger dogs. The red blood cell count and hemoglobin content of 4-5-year-old male dogs were significantly higher than those of 6-8 month-old female dogs and 8-9-year-old female dogs (P<0.05), and the erythrocyte sedimentation rate was significantly lower than that of 4-5-year-old and 8-9-year-old female dogs (P<0.05), but slightly higher than 6-8 months old younger dogs of the same gender, There were no significant differences observed in other indicators.Conclusion　The result indicated that the young dogs could be used as experimental animals withoud significant concern for the impact of hematological parameters; when choosing juvenile beagles as animal models, attention should be paid to the influence of red blood cells, platelets, and erythrocyte sedimentation rate; old dogs, due to their lower white blood cell count, could be used for specific disease research, but the influence of high erythrocyte sedimentation rate should be noted.

Key words: Beagle dog, blood routine index, age, sex

摘要： 目的　探讨年龄和性别对比格犬基础血液指标的影响。方法　采集育成期(6~8月)、青年期(2~3岁)、成 年期(4~5岁)和老年期(8~9岁)不同性别比格犬的血液,利用血细胞分析仪测定血液中白细胞、红细胞数量,血 红蛋白含量,红细胞压积,平均红细胞体积,红细胞体积分布宽度,平均红细胞血红蛋白量和红细胞沉降率等常规 指标,并对测定结果进行统计分析。结果　6~8月龄雌性比格犬血液中淋巴细胞数量显著高于雄性比格犬和8~9 岁雌性比格犬(P<0.05),红细胞数量和血红蛋白含量显著低于4~5岁雄性比格犬(P<0.05),红细胞沉降率显著 低于4~5岁和8~9岁雌性比格犬(P<0.05);2~3岁青年比格犬血液中血小板数量最低,红细胞沉降率显著低于 4~5岁和8~9岁雌性比格犬(P<0.05),但略高于6~8月龄比格犬;4~5岁雄性比格犬红细胞数和血红蛋白含量 均显著高于6~8月龄雌性比格犬和8~9岁雌性比格犬(P<0.05),红细胞沉降率显著低于4~5岁和8~9岁雌性比 格犬(P<0.05),但略高于6~8月龄同性比格犬;其余指标无明显差异。结论　青年比格犬用作实验动物可不考虑 血常规指标的影响;育成比格犬做动物模型时需要注意红细胞、血小板和红细胞沉降率的影响;老年比格犬由于白 细胞数量较少,可用于特定疾病的研究,但需注意高红细胞沉降率的影响。

关键词: 比格犬, 血常规指标, 年龄, 性别