Abstract: Objective　To investigate the effects of shape, color, and interval time on object position discrimination in mice.Methods　A total of 90 male C57 mice were randomly assigned to three groups: shape (27 mice), color (27 mice), and interval time (36 mice). Each group underwent tests involving various object shapes, colors, and test intervals to assess the object position discrimination index, which was used to evaluate the mice′s learning and memory abilities. Results　In the shape test, mice demonstrated the highest discrimination index for square objects (P<0.05). In contrast, there were no significant differences in the object discrimination index across different colors. For the interval time test, the discrimination indices were significantly higher for the 10-minute and 1-hour intervals (P<0.05). Conclusion　Both object shape and interval time appear to influence the object position discrimination test in mice. Specifically, a 1-hour interval between object presentation and square objects testing resulted in a higher discrimination index.

Key words: mice, object position discrimination test, learning and memory

摘要： 目的　探索物体形状、颜色及测试间隔时间等因素对小鼠物体位置辨别测试结果的影响。方法　将90只雄 性C57小鼠随机分为形状组(27只)、颜色组(27只)及测试间隔组(36只)。采用不同的物体形状、颜色及测试间 隔时间等因素检测各组小鼠物体位置辨别指数。结果　在不同物体形状测试中,小鼠对方形物体的辨别指数最高 (P<0.05);在不同物体颜色测试中,不同颜色的物体辨别指数没有差异;在不同间隔时间测试中,间隔10 min和 1 h测试的辨别指数较高(P<0.05)。结论　对于雄性C57小鼠,测试物体的形状以及间隔时间对物体辨别测试结 果有影响,选取方形物体以及间隔1 h测试的物体位置辨别指数较高。

关键词: 小鼠, 物体位置辨别测试, 学习记忆