关键词: 内膜增生, 再狭窄, 动物模型

Abstract: With the change of life style in modern society, the number of patients with atherosclerosis is increasing in recent years, and the number of patients requiring angioplasty is also increasing significantly. Existing treatment measures have a high incidence of post-operative restenosis. Clarifying the mechanisms of restenosis is of great significance for their prevention and treatment. At present, neointimal hyperplasia and restenosis model has been mature and widely used to simulate the situation of vascular restenosis after angioplasty. At present, there are a variety of arterial injury method to replicate the animal model of neointimal hyperplasia, such as balloon injury, wire injury, ligation, cuff injury. All of these method can cause intima hyperplasia and then lead to vascular stenosis. This paper will review the characteristics of various modeling method to summarize the advantages and disadvantages of each method, in order to find a most practical modeling method and provide references for experimental vascular disease studies.

Key words: neointimal hyperplasia, restenosis, animal model